Sudden 2013 Errors 'reading initial communication packet'

Today I'm suddenly experiencing the following error when a specific application attempts to connect to a database: ERROR 2013 (HY000): Lost connection to MySQL server at 'reading initial communication packet', system error: 0

There is another host running a near mirror-image of the app and isn't experiencing this error.

What are some things I should be looking for? I cannot recall any recent permissions modifications or changes in our network.


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