HANDLER statements give you direct access to reading rows from the storage engine. This is much faster than normal access through SELECT as there is less parsing involved and no optimizer involved.
You can use prepared statements for
HANDLER READ, which should give you a speed comparable to HandlerSocket. Also see Yoshinori Matsunobu's blog post Using MySQL as a NoSQL - A story for exceeding 750,000 qps on a commodity server.
HANDLER CommandsDirect access to table storage engine interfaces for key lookups and key or table scans.
HANDLER for MEMORY TablesUsing HANDLER commands efficiently with MEMORY/HEAP tables